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Patients typically exhibit symmetric, progressive muscle weakness and atrophy, ultimately leading to premature death due to respiratory and cardiovascular complications

Our results further show that efficient conversion depends on a defined balance between free thiolate and nitrosylated cysteine species, consistent with a mechanism in which transient S-nitrosylation facilitates thioldisulfide exchange

JamesSJCutlerPMelnykSJerniganSJanakLGaylorDWet al

This physiological process together with the renal Ca 2+ reabsorption and the bone Ca 2+ resorption maintain the Ca 2+ homeostasis
