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Whether endocrine therapy combined with metabolic therapy will achieve better results still needs a lot of preclinical studies and clinical trials to verify

Studies to date have investigated various anti-angiogenesis methods, including the use of nanoparticle drugs, to promote tumor vessel normalization and reverse drug resistance 75

Gee JM, Valderas MW, Kovach ME, et al

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However, neither of these drugs has improved OA symptoms in human clinical trials to date, likely because of the dynamic joint environment
