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Okada et al., 2017, demonstrated this method by derivatizing racemic SFN with (S)-leucine

Our results not only demonstrate the concomitant downregulation of GPX4 and upregulation of molecular pathways increasing LIP in the heart of diabetic patients but also unveil the potential mechanisms behind the diminished expression and activity of GPX4 in diabetic human hearts

"Multienzyme deep learning models improve peptide de novo sequencing by mass spectrometry proteomics." PLoS Computational Biology 19.1 (2023): e1010457