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Subject terms: Neurodevelopmental disorders, Diseases of the nervous system Introduction Diabetic neuropathy (DN) is among the most prevalent chronic complications of types 1 and 2 diabetes mellitus (T1DM and T2DM), significantly compromising patients quality of life and contributing to elevated morbidity and mortality rates

In addition to creatines role in rapid energy production during high-intensity exercise, it has been shown to exert other physiological effects, including upregulating the expression of various genes

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