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This produces hydrogen peroxide (H2O2), which decreases the activity of the dihydropteridine reductase (DHPR) enzyme.71,72 Furthermore, H2O2 negatively affects acetylcholinesterase (AchE) and xanthine oxidase (XO).73,74 Repair mechanisms and immune system activation in vitiligo patients could reduce the risk of skin cancer, which is attributed to immune activation capable of identifying and eliminating damaged cells, including those with potentially precancerous mutations

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20.4% CagriSema Trial REDEFINE 2 (NEJM 2025) Duration 68 weeks Population T2D + BMI 27 (n=1,206) Mean Weight Loss 13.7% CagriSema vs 3.4% placebo

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