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To that end, treatment of primary human airway smooth muscle cells, derived from nonasthmatic and fatal asthmatic subjects, with 2 -AR-agonists, demonstrated a reduced cAMP response and an increased accumulation of phosphorylated 2 -ARs in asthmatic human airway smooth muscle cells (Gupta et al., 2015)

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This model consists of five successive layers, namely the first layer (fuzzy formation), the second layer (fuzzy rules), the third layer (normalization of membership functions), the fourth layer (fuzzy rule conclusion section), and the fifth layer (output calculation)

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