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It is difficult, in this case, to distinguish acute hepatitis C from an acute exacerbation of chronic hepatitis C or an acute hepatitis of another cause in a patient with chronic hepatitis C

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In the injection study, three 10-day cycles of 0.16 mg/kg over three months produced significant melanin-density increases by reflectance spectroscopy, with subjects who had the lowest baseline melanin showing the largest relative gains (Barnetson et al., 2006)