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It emphasizes established and emerging risk factors, including environmental toxins, lifestyle variables, and gut microbiota dysbiosis and delineates how peripheralcentral pathways such as the gutbrain, erythrocytebrain, and kidneybrain axes contribute to PD pathogenesis

Regulated cell death, including apoptosis, pyroptosis, necroptosis, ferroptosis, autophagy-dependent cell death and neoplastic cell death, is a crucial mechanism for maintaining the internal homeostasis of the human body and preserving tissue function and morphology (8,9)