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90,91 Additionally, the activity of epigenetics-modifying enzymes and their cofactors, such as TET and -ketoglutarate (-KG) from the tricarboxylic acid cycle (TCA), can be influenced by abnormal metabolite levels in patients with metabolic diseases, further disrupting epigenetic regulation and exacerbating disease progression

Although cystine starvation has been shown to induce oxidative stress, we did not observe any increase in soluble or lipid ROS production in cystine-starved cells (Fig

Humans express two additional genes that are members of the PGAM gene family, neither of which encode proteins with phosphoglycerate mutase activity

phase I and phase II metabolic reactions