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Malnutrition also has a strong inhibitory effect on IGF-I, IGFBP-3 and ALS (18), and serum concentrations are reduced by conditions that affect nutrition, such as coeliac disease (19) and anorexia (20)

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CYP24A1, a gene that provides instructions for making the enzyme 24-hydroxylase, is involved in the catabolism of both 25(OH)VD 3 and 1,25(OH) 2 D 3, thereby limiting vitamin D receptor (VDR)/1,25(OH) 2 D 3 signaling 14

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