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A compound was classified as senolytic if it exhibited at least a 20% greater cytotoxicity in senescent cells compared with non-senescent cells
RBCs are particularly susceptible to oxidative stress due to the lack of nuclei needed for protein synthesis, the absence of mitochondria capable of supplying NADPH outside of the PPP, and a high iron content that drives Fenton chemistry 8
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BMC Genomics 16, 19
The glutathione system includes not only the tripeptide itself but also the enzymes responsible for its synthesis and recycling
