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doi:10.3389/fnut.2022.926043

Metabolic syndrome and the decreased levels of uric acid by leflunomide favor redox imbalance in patients with rheumatoid arthritis

However, this may be independent of cognitive changes (Johansson et al., 2022)
HPA Axis / Biomarkers Cadegiani & Kater (2017) EROS Study Resting cortisol is normal in 75% of OTS studies

Oxidative stress occurs when there is an imbalance between free radicals and antioxidants, leading to cellular damage
