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Successful isolation and long-term establishment of a cell line with stem cell-like features from an anaplastic medulloblastoma

These findings hinted that the decrease in the active tetrameric configuration of PKM2, brought on by the insulin-ATM signaling, is a downstream effector response regulating the catabolic versus anabolic fates of glucose and glutamine in cerebellum

Collectively the prior work support moving forward with a Phase II, placebo-controlled study of D+Q (NCT04685590)

Antioxidants 9 , 973 (2020)

A Phase 2 study published in the New England Journal of Medicine in 2023 (Jastreboff et al.) reported substantial weight loss in participants with obesity