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[DOI] [PubMed] [Google Scholar] Hartmann T.N., Fricker M.D., Rennenberg H., Meyer A.J
UV light, allergens, air pollution, and chemical or medical treatments, such as radiotherapy, are some factors that can damage the skin, impair barrier protection, and disrupt homeostasis 3

It is thick in the middle

First, it derives from a larger gastric protection protein

Nature 2011, 474, 192195