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Since doctors think they need to keep levels within that range, they wont inject too often

10.1016/j.vph.2015.03.005 [DOI] [PubMed] [Google Scholar] Stoppe C., McDonald B., Meybohm P., Christopher K

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The TME is widely associated with tumor occurrence because it is the carrier of tumor cells, which interacts with surrounding cells through the circulatory and the lymphatic system, thus influencing the development and progression of cancer