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PMCID: PMC8221130
Pathophysiology: Off J Int Soc For Pathophysiology
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This was confirmed in an additional cell line and with depletion of KG or suppression of KGDDs using knockdown/inhibition of IDH1, glutamine starvation, or succinate supplementation ( Fig
A ZDV-induced reduction in the amount of LC may be a major factor in mitochondrial alterations that lead to the accumulation of lipid droplets in the cytoplasm of muscle cells [93,94,117]
