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Notably, human gut microbiota can transform C -glycosides such as orientin and vitexin into their corresponding aglycones, luteolin and apigenin, suggesting an important role of the gut microbiota as a key contributor to their metabolic conversion (Wang S

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In SOD1 mouse models, end-stage disease is associated with higher markers of M1 activation (such as NOX2 and other reactive oxidative species) compared with higher levels of M2 activation (such as CD163 and brain-derived neurotrophic factor (BDNF)) at disease onset [242]

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