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Mitochondrial dysfunction in ASD Metabolic studies have linked mitochondria to the pathophysiology of ASD [64]

For non-pharmacological therapies, NPG members included acupuncture, cognitive behavioral therapy, physical activity, diet, and non-invasive brain stimulation (NIBS), using the same criteria as the search for pharmacological RCTs

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Accumulation of the long Hb S chains in an RBC causes a change in the shape (sickling) of RBCs, decreased deformability, and increased blood viscosity (34), resulting in peripheral vasoocclusion, a painful symptom

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