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Tehranian, C

pH-Responsive Nanocarriers : Due to the inherent acidic nature of TME, this environment is characterised to respond to pH sensitive nanocarriers

Too much copper and too little zinc can amplify oxidative stress, strain the brains antioxidant defenses, and interfere with neurotransmitter balance

Macrophages produce excessive pro-inflammatory cytokines like interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor- (TNF-), and inflammatory mediators such as prostaglandin E2 (PGE 2 ), nitric oxide (NO), and ROS, generated by activated cyclooxygenase (COX) and inducible nitric oxide synthase (iNOS) (Seon-Jin et al., 2003