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Its important to note here that the medical benefit ratio (MBR) reported by Aetna is not exactly the same as the one used in the trigger of the Vitality Re health ILS transactions, but sources tell us it tracks closely enough to be representative

10.1038/s41598-017-05005-9 84 MathewsV

A randomized, double-blind, placebo-controlled clinical trial conducted in 30 healthy Filipino women aged 30 to 50 years provided some evidence for the efficacy of a topical 2% GSSG lotion for temporary skin whitening
Their skeleton comprises 2-phenyl--pyrone, which is involved in the heterocyclic pyrone ring connected with two phenyl rings [59]
doi: 10.3389/fendo.2022.1011669