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Keywords: melanin index, melanogenesis, oxidized glutathione, reduced glutathione, skin whitening, topical Introduction Skin aging is a complex biological phenomenon consisting of two independent clinically and biologically distinct processes, namely intrinsic aging and extrinsic aging. 1 , 2 Extrinsic aging (including photoaging) is the result of exposure to outdoor elements, primarily ultraviolet (UV) irradiation

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