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Relative to cell growth and death and aging, ferroptosis had the highest enrichment score (Additional file 2: Figure S1)

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Skeletal muscle contraction also elicits both shear stress to the surrounding arteries due to increased local blood flow and increased muscle fiber intracellular calcium concentrations via excitationcontraction coupling ( NO production via the NOS-independent pathway In the NOS-independent pathway, NO production is the result of the sequential reduction of nitrate to nitrite to NO

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