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Figure 2 2.1 Ferroptosis and iron metabolism 2.1.1 Iron uptake, storage, and release Ferroptosis requires the involvement of iron ( 2+ and Fe 3+ ( 3+ and Fe 2+ through redox reactions, leading to tissue damage and ferroptosis ( 3+ has strong stability and is responsible for the storage and transportation of iron in the body

doi: 10.3389/fmicb.2011.00069 82

It is used in traditional Hindu medicine (Unani) as Arq-e-Afsanteen for liver irritation and obstruction, Dava-ul-Luk for abnormally inflamed liver or spleen and nephrolithiasis and Qurs-e-Gul for prolonged fever as a liver tonic and dysmenorrheal in the form decoctions from the plant