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Besides, in rats with inflamed intestines, PER downregulated the toll-like receptor 4 (TLR4), NF-B, and c-Fos/c-Jun pathways at the molecular level (Sayed et al

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In a breast cancer xenograft model (MDA-MB-231), mitochondria-targeted nanomedicines co-assembled from berberine and doxorubicin effectively repairs mitochondrial protein defects (Mfn1/Drp1) and inhibits the activity of MMP-2 and MMP-9, resulting in significant suppression of tumor cell proliferation and lung metastasis [242]

It also improves nutrient digestion and absorption, reduces the expression of inflammatory cytokines including TNF-, IL-6, and IFN-, and alleviates the damage to the jejunum and liver tissue caused by heat treatment

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