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Furthermore, single-nucleotide polymorphisms XBP1 in patients with vitiligo illuminate the importance of this pathway in the pathogenesis of vitiligo ( 5 Nrf2 Antioxidant response pathway Oxidative stress is considered as a major event in vitiligo pathogenesis (Figure 2A)

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Given that the G6PD trait represents the hemolytic disorder subtype contributing most substantially to PAH burden, coupled with its high prevalence, we propose that G6PD deficiency-related PAH warrants significantly greater attention