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Beyond skeletal muscle, AICAR-mediated AMPK activation has been implicated in improving insulin sensitivity [152], reducing hepatic lipid accumulation [153], and exerting cytoprotective effects under metabolic stress [154], further underscoring its importance as a molecular probe and potential metabolic modulator

BG concentrations are mea- sured before the morning insulin injection and then every 2 h until the evening dose is administered

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doi: 10.1016/j.jaci.2006.12.614 96 ZhangLZhangJYouZ
