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In a randomized, double-blind, placebo-controlled trial involving 127 ME/CFS patients, administration of Sijunzi Decoction demonstrated significant efficacy, as evidenced by reduced Chalder Fatigue Questionnaire (CFQ) scores and measurable alterations in gut microbiota composition [184]

Institutional Review Board Statement All the study procedures were found to be in accordance with the Helsinki Declaration of 1975/83

Ahlborg G, Jensen-Urstad M

Although it usually results in mild central nervous system depression, serious toxicity and even fatal cases have been reported

Fabiola De Marchi, Raffaele Dubbioso and Valentina Virginia Iuzzolino are members of the European Reference Network Euro-NMD
