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In a randomized, double-blind, placebo-controlled trial involving 127 ME/CFS patients, administration of Sijunzi Decoction demonstrated significant efficacy, as evidenced by reduced Chalder Fatigue Questionnaire (CFQ) scores and measurable alterations in gut microbiota composition [184]

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Institutional Review Board Statement All the study procedures were found to be in accordance with the Helsinki Declaration of 1975/83

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Ahlborg G, Jensen-Urstad M

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Although it usually results in mild central nervous system depression, serious toxicity and even fatal cases have been reported

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Fabiola De Marchi, Raffaele Dubbioso and Valentina Virginia Iuzzolino are members of the European Reference Network Euro-NMD

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