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The function of NRF2 is ubiquitously conserved across different cell types, but it is widely expressed in the central nervous system (CNS), where it regulates a range of functions including redox balance, xenobiotic metabolism, inflammation, and proteostasis (Cuadrado 2022)

[DOI] [PubMed] [Google Scholar] 195.Zemba Cilic A., Zemba M., Cilic M., Strbe S., Ilic S., Vukojevic J., Zoricic Z., Filipcic I., Kokot A., Smoday I.M., et al

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,,SuLJ,ZhangJH,GomezH,MuruganR,HongXXuDet al.Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis.2019;2019:5080843

The proposed mechanisms include reducing inflammation, enhancing mitochondrial function, and promoting neuronal survival