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In TLE and cortical developmental malformations, translocation of HMGB1 impacts upregulation of TLR4 and RAGE (also activated by HMGB1) in neurons and astrocytes (196, 197)

Under osmotic stress, cells upregulate aquaporins, osmolyte transporters, and enzymes for the biosynthesis of compatible solutes such as proline, trehalose, and glycine betaine (Szabados and Savour, 2010

4B, the supernatant of EBC-1 cells transfected with siHDGF#761 significantly, but not completely, suppressed tube formation compared to those treated with vehicle or siControl (Fig

BehrJBendstrupECrestaniBGntherAOlschewskiHSkldCet al
