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Drug resistance to targeted therapies: Deja vu all over again

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Diminished UPR activation at both the protein (Figure 8C) and mRNA (Figure 8D) levels indicated that MPC1-deficient cells were also remarkably resistant to ER stress induced by TM or by the ER calcium-disrupting agent thapsigargin (TG)

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Dose Range: 200600 mcg, using a gradual step-up approach
