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The result of methyl transfer is the conversion of SAM to S-adenosylhomocysteine (SAH or AdoHcy)

These investigations, along with others, have contributed to the development of the current hypothesis for CBR distribution, which states that CB1 is largely found in brain and nearby structures like the pituitary (51) and peripheral nervous tissues (52), while CB2 is largely found in the immunological and reproductive systems

In fact, since the ratio GSH:GSSG is only 1:10 and considered that GSH oxidation is favored, GSSG quantification was considered a difficult procedure

In the course of evolution, nature has optimized several glutathione-utilizing enzymes as efficient tools for their detoxification [8]

Biochem Pharmacol 186:114486