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SAIF also inhibits angiogenic mediators such as VEGF, bFGF, and PDGF, which directly impair neovascularization, in vivo (Fig
The peptide exerts additional effects through inhibition of enkephalinases, enzymes that break down the brains natural opioid peptides called enkephalins
The practical takeaway here is that cagrilintide represents a genuinely new approach, not just a variation on existing GLP-1 medications
