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AIF was proposed before the concept of ferroptosis, and it has been involved in the study of apoptosis

[DOI] [PMC free article] [PubMed] 140.Zhao NO, Topolski N, Tusconi M, Salarda EM, Busby CW, Lima CNNC, et al

Conte, G

Another significant metformin side effect: vitamin B12 deficiency

GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically