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Herein, we construct a drug delivery system with precise targeting to tumors utilizing dual-controlled multifunctional nanocomposites, DOX/SOR@SP94 and mPEG-anchored MONs@MOF199 (D/S@SPMM), based on in situ growth of copper MOF on MONs as nanocarriers for improved HCC therapy (Scheme 1)

By inhibiting the biological effects of bradykinin or other inflammatory mediators and changing the route for the manufacture of prostaglandins, saponins can display their anti-inflammatory activities [40]

Planta Med 60:417420 Jin L, Baillie TA (1997) Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats

*Correspondence: Cyriac Abby Philips, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Cardiovascular diseases and diabetes mellitus were the most frequent comorbidities among these patients ( Table 1 )