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Description
The ChaC family (ChaC1 and ChaC2, cytoplasmic glutathione-specific -glutamyl cyclotransferases) has recently been shown to take part in GSH metabolism

Acetaminophen toxicity in fed and fasted mice

10.1016/j.neulet.2013.05.008 31 HimadriP.KumariS

[PubMed ID: 30177807]

In contrast to saline-injected WT mice, saline-injected Gpx1 KO mice showed low GSH/GSSG ratio, increased hydrogen peroxide and high MDA level in the liver and spleen (Figure 6)
