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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Mulhall JP, Trost LW, Brannigan RE, et al

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Both preclinical (in vitro and in vivo) and clinical studies were considered for inclusion to provide a broad perspective on the current state of evidence

The HIF-1-regulated genes included vascular endothelial growth factor (VEGF), glucose transporters (GLUTs), pyruvate dehydrogenase kinase 1 (PDK1), erythropoietin, insulin-like growth factor 2 (IGF-2), transforming growth factor , B-cell lymphoma 2 (BCL-2), BCL-2 interacting protein 3 (BNIP3), and heme oxygenase-1 (HO-1) 23