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therefore, all offspring of an affected mother will inherit the mtDNA mutation, but only daughters will transmit it to the next generation [1,2,11]

Compared with active comparators, ALC was associated with a more favorable adverse event profile, further supporting its potential role as a safer therapeutic option, especially for vulnerable populations

These processes are essential for human brain development because they represent a quality control system that prevents brain contamination with the toxic products of damaged molecules and cellular structures [243]

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For the mixed spheroids, LEC were collected 48 h after transfection and labeled with cell membrane labeling lipophilic dyes CellVue Jade and CellVue NIR780 (88-0876-16 and 88-0875-16 respectively, Thermo Fisher Scientific)