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Description
Allergic Reactions : Those with fish, shellfish, or egg allergies should be cautious if the collagen is marine-based or derived from egg membranes
This resistance was initially thought to be secondary to a significant decrease in surface CD38 following antibody exposure
In addition to its direct antitumor effects, daratumumab exerts an indirect immunomodulatory role by eliminating CD38 + immunosuppressive cell types (Treg, Breg and myeloid-derived suppressor cells) in the tumor microenvironment (TME), thereby promoting T-cell proliferation and effector functions [44]
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