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Likewise, angiogenesis plays a critical role in tumor growth, invasion and metastasis (Semela and Dufour, 2004)

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The maintenance of this delicate equilibrium is tightly regulated as it is essential for human homeostasis

Nuclear p53 induces autophagy through the transcriptional activation of ATGs, lysosomal genes, and upstream regulators such as TFEB, contributing to tumor suppression and stress adaptation

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