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doi: 10.1186/1472-6750-12-26 210 WierzchowskaK.ZieniukB.NowakD.FabiszewskaA

Topical Copper Peptides Affects surface layers of skin only Limited penetration through skin barrier Localized effect only where applied Good for maintenance, not transformation No systemic anti-aging benefit Available over-the-counter Injectable GHK-Cu Full systemic delivery to all tissues Reaches dermis, follicles, and healing sites Whole-body anti-aging effect More potent collagen stimulation Gene expression modulation (4,000+ genes) Requires medical prescription They are not mutually exclusive

Dagmar Bartkov (Diabetologick ambulance Milan Kvapil s.r.o., Prague)

Drugs Metabolized by the Mercapturate Pathway or by the Mercapturate/-Lyase Pathway Examples of drug electrophiles (discussed by Silverman, 1992) that are metabolized in part by pathways involving glutathione S -conjugate formation include the anticancer drug busulfan (see the succeeding text), the vasodilator nitroglycerin (Needleman et al., 1969), and the immunosuppressive drug azathioprine (de Miranda et al., 1975)