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4.4 Neonatal hypoxicischemic encephalopathy The pathophysiology of HIE involves hypoxicischemic injury, characterized by perturbations in mitochondrial dynamics and the inhibition of critical energy-producing pathways, including oxidative phosphorylation and fatty acid -oxidation ( -oxidation and its prior neuroprotective effects in adult ischemia models, it represents a biologically plausible candidate for investigation in neonatal brain injury

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doi: 10.1177/0333102414530527, PMID: [DOI] [PubMed] [Google Scholar] 224.Espiritu AI, Del Mundo HC, Bico JDP, Pasco PMD