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The evidence: A 2025 RCT published in Frontiers in Nutrition randomized 80 patients to 3,000 mg/day low-molecular-weight collagen peptides or placebo for 180 days
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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443454

Nighot, P
Arthritis Rheum (2013) 65(6):161223.10.1002/art.37914 131 GalloPMRapsinskiGJWilsonRPOppongGOSriramUGoulianMet alAmyloid-DNA composites of bacterial biofilms stimulate autoimmunity