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The implications of NNMT inhibition extend far beyond simple cofactor availability, influencing fundamental cellular processes including mitochondrial biogenesis, oxidative stress management, and epigenetic regulation

In the animal models, inhibiting or knocking down NNMT improved markers tied to glucose handling and lowered cholesterol

Some practitioners implement cycling approaches (such as 12 weeks on, 4-8 weeks off), though no published research directly compares continuous versus cycled protocols

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