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Together with the kinetic model and its full numerics of the expression derived for the doseresponse relation, an approximated form of the expression clarifies the role played by the individual biochemical processes and allows us to identify four distinct regimes for the downregulation that emerge from the balance between phosphorylation, dephosphorylation, and the cellular level of -arrestin.
Results A total of 20 studies, encompassing 44 independent experiments and involving 1019 animals, were included in the analysis
