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doi: 10.1002/(sici)1097-0142(19990501)85:9 3.0.co;2-2

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A borderline range of 200300 pg/mL may require further testing, such as MMA (methylmalonic acid) or homocysteine levels, to confirm deficiency and assess the need for supplementation or dietary changes.

In such cases, a temporary filling agent, such as Restylane or Juvederm, can be placed in the valley to plump up the depression, improving the appearance of dark circles under the eyes