spotting melanotic gingiva Oral macula on the upper gingival mucosa on a 40-year-old Oral pigmented lesions: Clinicopathologic features

2013 Crouthamel, MH

The production of ROS and inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), transforming growth factor 1 beta (TGF-1), and interleukin-6 (IL-6) results in inflammation which causes tissue damage and directly induces DNA damage (Damm et al

Not suitable for children under 14 years

In primary breast cancer lesions, mitochondrial dysfunction in adipocytes induces IL-6mediated lipolysis and the release of free fatty acids, which are then utilized by tumor cells and Tregs [129], simultaneously fueling malignancy and suppressing antitumor immunity

Tynterova AM, Belousova YD, Reznik EY