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All mechanistic insights are derived from rodent or in vitro models, and their relevance to human liver development is yet to be confirmed

Approximately 300 patients with a documented diagnosis of FA (including confirmation via genetic testing) and who are enrolled in the Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study (UNIFAI

Therefore, multiple lines of evidence link inflammasome-mediated pyroptosis to the generation of anti-nuclear and/or anti-dsDNA antibodies

This is why all B12 treatments experts advise not to retest B12 levels after treatment has begun as they are not a reliable guide to whether treatment is being effective