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RobinsonAMWilliamsonDH.Physiological roles of ketone bodies as substrates and signals in mammalian tissues

( Trimethylamine N-oxide (TMAO) is a metabolite of the intestinal flora that appears to play a major role in CVD

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However, oral L-arginine has limitations

Because the mucosal membrane in the intestine is the first line of protection against luminal microbiota, this deterioration could be a precursor to dysbiosis and CD