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Van Herreweghe F, Mao J, Chaplen FW, Grooten J, Gevaert K, Vandekerckhove J, et al

MR-spectroscopic imaging during visual stimulation in subgroups of migraine with aura

Under normoxic conditions approximately 75% of erythrocyte glucose is shunted to the pentose phosphate pathway for the production of NADPH in order to efficiently couple this with the anti-oxidant glutathione (GSH) cycle, thereby limiting the amount of reactive oxygen species (ROS) in the erythrocyte

Arachidonic acid 12 lipoxygenase (ALOX12) is also closely associated with p53-mediated ferroptosis ( TP53-induced glycolysis and apoptosis regulator (TIGAR) is a target gene of p53 that inhibits cancer and has an antioxidant effect ( p53 can also promote ferroptosis by influencing the function of ferredoxin reductase (FDXR) in iron metabolism (Zhang et al., 2017)