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c , Quantification of the total phosphoribosylated peptides normalized to the total peptides (top panel), the total phosphoribosylated viral peptides normalized to the total peptides and total viral peptides (2 nd and 3 rd panel from top) in lysates of HeLa cells stably expressing wildtype NAMPT or the NAMPT-H247E mutant, and that of the phosphoribosylated viral peptides normalized to the total viral peptides of HSV-1 virions produced from HeLa cells expressing wildtype NAMPT or NAMPT-H247E (bottom panel)

Carriers of a homozygous mutation on this gene would look like T 677 T

Here we describe the synthesis and kinetic characterization of a fluoromethyl-M(5) analogue that acts as a mechanism-based inhibitor of both enzymes
J Chem Stud
